Knitted cell scaffolds
AssigneeMassachusetts Institute of Technology
InventorsSteven R. Gillmer, Ming Guo, Erin Doran, Emily Holtzman, Ariel Sandberg, Matthew Bernasconi
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Abstract
Knit scaffolds for culturing cells and aiding in the healing of functional tissue are provided. The knit scaffolds have properties aligned with specific tissues for providing optimal tissue growing surfaces including matched biomechanical properties. The scaffolds are made up of knitted material and do not require or utilize a support skeleton for function. Methods of making and using the knit scaffolds are also provided.
Claims29
A three-dimensional knit scaffold comprising biocompatible fibers arranged in a knit sequence and comprising a microscopic and macroscopic porosity, wherein the scaffold has an elasticity value and an anisotropy value matched to a target tissue.
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A method for preparing a tissue scaffold, comprising:
- identifying a set of values defining an elasticity, anisotropy, healing rate, and/or hydraulic permeability value of a target tissue, and
- knitting monofilament or multifilament biocompatible fibers to produce a scaffold arranged in a knit sequence and comprising a microscopic porosity sufficient to support growing cells compatible with target tissue recovery, macroscopic porosity matched to the required hydraulic permeability of the target tissue, degradation rate which degrades at a similar rate to the healing rate of the target tissue, and having anisotropy biomechanical values matched to that of the target tissue.
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Dependencies are inferred from the claim text.