Adhesion suppressing material of biological substances

A cured product of a polymer of a monomer mixture which comprises

• an anionic monomer represented by the following formula (A):
• wherein
• Ta, Ua1 and Ua2 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms;
• Qa represents a single bond, an ester bond or an amide bond;
• Ra represents a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom(s);
• and
• m represents an integer of 1 to 10,
• a cationic monomer represented by the following formula (B):
• wherein
• Tb, Ub1, Ub2 and Ub3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms;
• Qb represents a single bond, an ester bond or an amide bond;
• Rb represents a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom(s);
• and
• An− represents an anion selected from the group consisting of a halide ion, an inorganic acid ion, a hydroxide ion and an isothiocyanate ion,
• a hydrophobic monomer represented by the following formula (C):
• wherein
• Tc represents a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms;
• Qc represents a single bond, an ether bond or an ester bond;
• Rc represents a linear or branched alkyl group having 1 to 18 carbon atoms, a cyclic hydrocarbon group having 3 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, an aralkyl group having 7 to 14 carbon atoms or an aryloxyalkyl group having 7 to 14 carbon atoms, where the aryl portion may be substituted by a linear or branched alkyl group having 1 to 5 carbon atoms which may be substituted by a halogen atom(s), and
• a bifunctional monomer represented by the following formula (D):
• wherein
• Td represents a hydrogen atom or a linear or branched alkyl group having 1 to 6 carbon atoms;
• Rd represents a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom(s);
• and
• n represents an integer of 1 to 10,
• where a ratio of a total of the anionic monomer represented by the above-mentioned formula (A) and the cationic monomer represented by the above-mentioned formula (B) based on total monomers contained in the monomer mixture is 40 mol % or more.

A process for producing a cured product, which comprises

• (i) a step of polymerizing a monomer mixture containing an anionic monomer represented by the following formula (A):
• wherein
• Ta, Ua1 and Ua2 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms;
• Qa represents a single bond, an ester bond or an amide bond;
• Ra represents a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom(s);
• and
• m represents an integer of 1 to 10,
• a cationic monomer represented by the following formula (B):
• wherein
• Tb, Ub1, Ub2 and Ub3 each independently represent a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms;
• Qb represents a single bond, an ester bond or an amide bond;
• Rb represents a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom(s);
• and
• An− represents an anion selected from the group consisting of a halide ion, an inorganic acid ion, a hydroxide ion and an isothiocyanate ion,
• a hydrophobic monomer represented by the following formula (C):
• wherein
• Tc represents a hydrogen atom or a linear or branched alkyl group having 1 to 5 carbon atoms;
• Qc represents a single bond, an ether bond or an ester bond;
• Rc represents a linear or branched alkyl group having 1 to 18 carbon atoms, a cyclic hydrocarbon group having 3 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, an aralkyl group having 7 to 14 carbon atoms or an aryloxyalkyl group having 7 to 14 carbon atoms, where the aryl portion may be substituted by a linear or branched alkyl group having 1 to 5 carbon atoms which may be substituted by a halogen atom(s), and
• a bifunctional monomer represented by the following formula (D):
• wherein
• Td represents a hydrogen atom or a linear or branched alkyl group having 1 to 6 carbon atoms;
• Rd represents a linear or branched alkylene group having 1 to 10 carbon atoms which may be substituted by a halogen atom(s);
• and
• n represents an integer of 1 to 10,
• where a ratio of a total of the anionic monomer represented by the formula (A) and the cationic monomer represented by the formula (B) based on total monomers contained in the monomer mixture is 40 mol % or more to obtain a copolymer, and
• (ii) a step of reacting the copolymer with a polycarbodiimide containing the structure represented by the following formula (E):
• to obtain a cured product.