Devices for injecting collagenase disrupting agent(s) and methods of treating conditions with thickened fascia such as dupuytren's contracture and ledderhose's disease

A multi-injector device for use in treating Dupuytren's Contracture or Ledderhose's Disease with simultaneous and spaced-apart injections of a therapeutic agent, comprising:

• a first therapeutic agent reservoir comprising a plunger operatively associated with the first therapeutic agent reservoir;
• a second, intermediate reservoir in fluid communication with the first therapeutic agent reservoir;
• and
• two or more injection reservoirs, each one of the two or more injection reservoirs comprising an injection needle comprising a lumen and distal aperture in fluid communication and operative association therewith,
• wherein adjacent ones of the two or more injection reservoirs and associated injection needles are spaced apart a distance and wherein the two or more injection reservoirs and associated injection needles are arranged in a linear pattern,
• wherein the plunger is configured to pressure a therapeutic agent from the first therapeutic agent reservoir into the second, intermediate reservoir and into each one of the two or more injection reservoirs,
• wherein the plunger is further configured to pressure the therapeutic agent from each one of the two or more injection reservoirs and through the associated injection needle's lumen and distal aperture.

A multi-injector device for use in treating Dupuytren's Contracture or Ledderhose's Disease with simultaneous spaced-apart injections of a therapeutic agent, comprising:

• a therapeutic agent syringe comprising a therapeutic agent reservoir configured to hold at least a therapeutic dose of the therapeutic agent, the therapeutic agent reservoir comprising a distal end and a plunger in fluid communication and operative association with the therapeutic agent reservoir and configured to pressure the therapeutic agent out of the distal end of the therapeutic agent reservoir;
• a base having a top surface and a bottom surface, the bottom surface in fluid communication with the distal end of the therapeutic agent reservoir;
• two or more flow channels defined by the base and in fluid communication with the distal end of the therapeutic agent reservoir;
• two or more injector devices,
• wherein each one of the injector devices comprises:
• an injector reservoir in fluid communication with one of the flow channels, and
• an injection needle in fluid communication with the injector reservoir, the needle comprising a lumen therethrough and a distal aperture,
• wherein the two or more injection needles are arranged in a pattern.