Regeneration or rejuvenation of tissues and organs

A method of regenerating and/or rejuvenating a function of an injured, damaged, aged, or diseased tissue or an injured, damaged, aged, or diseased organ in an individual, the method comprising:

• administering to the individual a 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor and/or a prostaglandin E2 (PGE2) activator in an amount effective to inhibit 15-PGDH expression or activity and/or increase PGE2 synthesis or activity in the individual, thereby regenerating and/or rejuvenating the function of the injured, damaged, aged, or diseased tissue or the injured, damaged, aged, or diseased organ in the individual, wherein the 15-PGDH inhibitor and/or PGE2 activator is selected from the group consisting of:
• a nucleic acid molecule or polypeptide capable of inhibiting 15-PGDH expression, a nucleic acid molecule or polypeptide capable of enhancing PGE2 synthesis, a gene editing system capable of inhibiting 15-PGDH expression, a gene editing system capable of enhancing PGE2 synthesis, an epigenetic modification capable of inhibiting 15-PGDH expression, an epigenetic modification capable of enhancing PGE2 synthesis, and combinations thereof.