Methods for magnetic resonance imaging of nanoconstructs and uses thereof

A method of imaging a magnetic resonance imaging (MRI) agent, the method comprising the steps of:

• (a) administering the MRI agent to a subject,
• wherein the MRI agent comprises nanoconstructs each having a plurality of equivalent protons and an average molecular weight in a range of about 300 Da to about 300 kDa and the nanoconstructs each have a T2 relaxation time greater than at least about 250 ms;
• (b) using an MRI device to obtain a nuclear magnetic resonance scan of the nanoconstructs, wherein step (b) comprises:
• (i) applying diffusion filtering to suppress water signals from the scan and selectively imaging the nanoconstructs;
• (ii) applying a signal acquisition bandwidth ranging from at least about 2 kHz to about 200 KHz;
• and
• (iii) obtaining greater than 8 spin echoes, optionally between 9 and 64 or between 9 and 128 spin echoes;
• optionally wherein step (b) further comprises modifying gain of a receiver-amplifier of the MRI device.