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AssigneeFlagship Pioneering Innovations Vii, LLC
InventorsEllen Lovisa Larsdotter AFZELIUS, Hozefa Saifuddin BANDUKWALA, Brendan Peltonen LEHNERT, Erika GONZALEZ RODRIGUEZ
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Provided herein are engineered Plasmodia comprising a heterologous nucleic acid molecule encoding a therapeutic protein and compositions (e.g., pharmaceutical compositions) comprising the same; as well as methods of making engineered Plasmodia comprising a heterologous nucleic acid molecule encoding a therapeutic protein and compositions (e.g., pharmaceutical compositions) comprising the same. The engineered Plasmodia provided herein are useful e.g., in pharmaceutical compositions and methods of treating diseases.
An engineered Plasmodium comprising a heterologous nucleic acid molecule within a genome of the Plasmodium, wherein the heterologous nucleic acid molecule encodes a therapeutic protein.
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A method of making an engineered Plasmodium, the method comprising:
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A kit comprising a vessel (i) configured for drawing blood from a human patient and (ii) comprising an engineered Plasmodium comprising in its genome a heterologous nucleic acid molecule encoding a therapeutic protein.
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The kit of claim 7, wherein the vessel comprises a population of hRBCs comprising the engineered Plasmodium.
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A kit comprising the therapeutic protein made by the method of 51.
Dependencies are inferred from the claim text.