Integrated cartridge assembly for administration of drugs

A cartridge assembly configured to be operatively coupled to a pump assembly and a medical port, the cartridge assembly comprising:

• a housing defining an internal volume, a proximal end portion of the housing defining an access orifice and an actuation slot;
• a cartridge including a container body, a frangible seal coupled to the a distal end portion of the container body, and an elastomeric member disposed within a proximal end portion of the container body, the cartridge positioned within the internal volume with the elastomeric member aligned with the access orifice and an end portion of the container body aligned with the actuation slot;
• a manifold assembly positioned within the internal volume, the manifold assembly coupled between the medical port and the proximal end portion of the container body, the manifold assembly including a puncturer configured to selectively fluidically couple the medical port and the cartridge;
• on a condition that the cartridge assembly is coupled to the pump assembly, the actuation slot is configured to receive an actuation member of the pump assembly, the cartridge being configured to move in a distal direction within the housing such that the puncturer of the manifold assembly pierces the frangible seal in response to a force exerted by the actuation member on the end portion of the container body;
• and
• on the condition that the cartridge assembly is coupled to the pump assembly, the access orifice is configured to receive a drive member of the pump assembly, the elastomeric member configured to be moved in a distal direction within the container body to convey a medicament into the manifold assembly in response to a force exerted by the drive member on the elastomeric member.