Drug regimen for treatment of cerebral ischemia
AssigneeShimojani, LLC
InventorsLawrence M. KAUVAR, Damir JANIGRO
Life of this patent
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Abstract
Treatment of subjects experiencing cerebral ischemia is improved when the treatment employs a thrombolytic and an inhibitor against vascular endothelial growth factor receptor signal transduction (VEGF-RST) at a reduced, low dosage compared to that used to treat cancer patients. The treatment is also improved to permit point-of-care use by formulating protein drugs for long term stability at room temperature, providing doses appropriate for the method, and by combining the therapeutic agents with a point-of-care diagnostic for blood brain barrier integrity.
Claims18
A method of treatment to reduce neuronal damage caused by a cerebral ischemic event in a human patient said method comprising administering to said patient an effective amount of a thrombolytic and an effective amount of an inhibitor of vascular endothelial growth factor (VEGF) receptor-mediated signal transduction (VEGF-RST) wherein the effective amount of said inhibitor provides acute inhibition but does not inhibit long term.
A kit comprising components which are a thrombolytic and an inhibitor of VEGFRST wherein the inhibitor of VEGF-RST is in a measured dose in the range of 0.1% to 5% of the dose used to treat cancer.
A method of treatment to reduce neuronal damage caused by a cerebral ischemic event in a human patient said method comprising mechanically removing a blood clot associated with said ischemia event and administering in association with said removing a measured dose of an inhibitor of VEGF-RST effective to inhibit >50% of signal transduction over 24 hours.
Dependencies are inferred from the claim text.