Compositions, systems, and methods related to transgenic hookworms as a drug production and delivery technology
AssigneeWashington University
InventorsMakedonka Mitreva, Sergej Djuranovic
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Abstract
Among the various aspects of the present disclosure is the provision of transgenic hookworm compositions and systems and methods of use thereof. The present teachings include compositions for a transgenic hookworm that treats a disease, condition, or indication. Also disclosed is a personal protective biosystem based on the transgenic hookworm, and methods to treat a disease, condition, or indication of a subject using transgenic hookworm compositions.
Claims16
A composition for the treatment of a disease, condition, or indication in a patient in need, the composition comprising a transgenic hookworm configured to release at least one therapeutic agent, the transgenic hookworm comprising a hookworm genome with a configurable chassis inserted, the configurable chassis comprising:
- a. at least one transgenic DNA sequence encoding at least one therapeutic agent, wherein the at least one transgenic DNA sequence encodes the at least one therapeutic agent;
- b. at least one promoter DNA sequence operatively linked to the at least one transgenic DNA sequence, the at least one promoter DNA sequence encoding at least one promotor configured to drive expression of the at least one transgenic DNA sequence;
- and
- c. at least one regulatory DNA sequence operatively linked to the at least one transgenic DNA sequence, the at least one regulatory DNA sequence configured to enhance production of the at least one therapeutic agent.
A method to treat a disease, condition, or indication in a subject, the method comprising:
- a. providing a composition comprising a transgenic hookworm configured to release at least one therapeutic agent, the transgenic hookworm comprising a hookworm genome with a configurable chassis inserted, the configurable chassis comprising:
- i. at least one transgenic DNA sequence encoding at least one therapeutic agent, wherein the at least one transgenic DNA sequence encodes the at least one therapeutic agent,
- ii. at least one promoter DNA sequence operatively linked to the at least one transgenic DNA sequence, the at least one promoter DNA sequence encoding at least one promotor configured to drive expression of the at least one transgenic DNA sequence;
- and
- iii. at least one regulatory DNA sequence operatively linked to the at least one transgenic DNA sequence, the at least one regulatory DNA sequence configured to enhance production of the at least one therapeutic agent;
- and
- b. administering the transgenic hookworm to the gut of the subject.
Dependencies are inferred from the claim text.