Integrated virtual patient framework

A method for therapeutic decision support associated with a patient in an Integrated Virtual Patient Framework (IVPF), comprising:

• receiving first demographic data associated with the patient that comprises a plurality of biomarkers;
• defining a plurality of disease-specific models in accordance with the first demographic data that provide therapeutic decision support in accordance with a temporal relationship with multiple timepoints for a patient diagnosed with a condition;
• determining, by a computing device, a first therapeutic decision by applying first weights to each of the plurality of disease-specific models;
• ranking, by the computing device, therapy choices of the first therapeutic decision in a user interface;
• receiving second demographic data after applying a therapy to the patient based on the ranking;
• comparing the second demographic data to virtual patent data in a database of simulated outcomes determined using the plurality of disease-specific models;
• determining, in accordance with the comparing, a subsequent therapeutic decision by applying adjusted weights to the plurality of disease-specific models;
• ranking subsequent therapy choices of the subsequent therapeutic decision in the user interface to provide for continuous refinement of the subsequent therapeutic decision;
• and
• determining, by the computing device, an optimal outcome based on the subsequent therapy choices.