US 2024/0402477 A1 · MULTISCALE LENS SYSTEMS AND METHODS FOR IMAGING WELL PLATES AND INCLUDING EVENT-BASED DETECTION

Abstract

Multiscale lens systems and methods for imaging well plates and including event-based detection is disclosed. In some embodiments, the multiscale lens systems and methods provide a multiple read-head optical detection system, a step-and-shoot optical detection system, a multiscale microlens optical detection system, and/or a multiscale GRIN lens optical detection system. Further, a fluidics system may include a liquid handling system and a multiscale optical detection system in relation to a well plate. Further, a method of using a multiple read-head optical detection system is provided. Further, a method of using a step-and-shoot optical detection system is provided. Further, a method of using a lens array optical detection system is provided.

Claims20

Dependent claims

A system configured to image a surface, comprising:

(a) a first light source and a second light source configured to illuminate a first surface of a well, wherein the first light source and the second light source are separated at a distance of less than about 500 nanometers:
(b) an optical element configured to couple emitted light of the first light source and the second light source from a second surface of the well, wherein the second surface of the well is axially separated from the first surface of the well along an optical axis parallel to an optical axis of the first light source or an optical axis of the second light source, and wherein the optical element comprises a plurality of lens elements;
and
(c) a detector optically coupled to the optical element, wherein the detector is configured to detect the light emitted from the second surface of the well.

1 more element

Dependencies are inferred from the claim text.

Multiscale lens systems and methods for imaging well plates and including event-based detection

Life of this patent

Multiscale lens systems and methods for imaging well plates and including event-based detection

Life of this patent

Abstract

Claims20