A compound of formula C-B, or pharmaceutically acceptable salts, stereoisomers, mixtures of stereoisomers, tautomers, hydrates, and/or solvates thereof, wherein C is a group of formula 13 or 14:
- and B is a group of formula 3, 4, 9, 10, or 11:
- wherein,
- each Q is independently a group of formula —(CR12R13)—, O or Si(CH3)2, provided that each O and each Si(CH3)2 is not directly bonded to O or Si(CH3)2;
- each of R1 and R2 is independently H, D, or C1-C6 alkyl;
- or R1 and R2 together form a 5-membered heterocyclic ring or a 6-membered heterocyclic ring;
- R3 is independently H, D, F, Cl, Br, I, C1-C6 alkyl or C1-C6 alkoxy;
- each W is independently C (carbon) or N (nitrogen) and wherein for each use of W=W, the bond between each W can be a single bond or double bond and further provided that if a single bond, each C (carbon) atom will have a hydrogen atom linked hereto in addition to one of R4, R5, R6 or R7;
- and where:
- (i) if W is C (carbon), each of R4, R5, R6 and R7 attached thereto is independently H, D, F, Cl, Br, I, C1-C6 alkyl or C1-C6 alkoxy, and (ii) if W is N (nitrogen), each of R4, R5, R6 and R7 attached thereto is independently absent or selected from H, D or C1-C6 alkyl;
- L is absent or —(CR12R13)—;
- each X is independently a group of formula —(CR12R13)—;
- each Y is independently absent or a group of formula —(CR12R13)—;
- each Z is independently a group of formula —(CR14)—;
- each of R8 and R9 is each independently H, D, F, Cl, Br, I, C1-C4 alkyl or C1-C8 alkoxy;
- or taken together R8 and R9, of a group of the formula —(CR8R9)—, —(CR8R9) or —(CR8R9R10), form a 3-, 4-, 5-, 6- or 7-membered carbocyclic or heterocyclic ring;
- each R8′, R9′ and R10′ is independently Cl, Br, I or C1-C4 alkyl;
- or taken together R8′ and R9′ form a 3-, 4-, 5-, 6- or 7-membered carbocyclic or heterocyclic ring;
- R10 is H, D, F, Cl, Br, I, C1-C6 alkyl or C1-C6 alkoxy;
- each R12, R13 and R14 is independently H, D, F, Cl, Br, I, C1-C8 alkyl, C1-C8 alkoxy, C3-C6 cycloalkyl, C1-C6 alkenyl, C1-C6 alkynyl, C1-C6 heteroalkyl, C6-C14 aryl or —NR22R23;
- or taken together R12 and R13, of a group of the formula —(CR12R13)—, form a 3-, 4-, 5-, 6- or 7-membered carbocyclic or heterocyclic ring;
- each R19 is independently H, C1-C4 alkyl, (unsubstituted or substituted) benzyl, R24C(O)—, R24OC(O)—, R24R25NC(O)—, or (R24O)(R25O)P(O)—;
- R20 is H, D, F, or C1-C12 alkyl or C3-C6 cycloalkyl;
- each R21 is independently H, D, F, Cl, Br, I, or C1-C4 alkyl;
- each of R22 and R23 is independently H, D, C1-C4 alkyl;
- or taken together, the R22 and R23 of the group of formula —NR22R23 form a 3-, 4-, 5-, 6- or 7-membered carbocyclic or heterocyclic ring,
- each of R24 and R25 is independently H, D, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, arylheteroalkyl, heteroarylheteroalkyl or T, wherein T is —(CH2)w—(O)x—[(CH2CH2)—O]q—R26;
- R26 is H, methyl, ethyl, isopropyl, or tert-butyl;
- m is 0 or 1;
- n is an integer from 0 to 12, inclusive;
- p is an integer from 0 to 20, inclusive;
- q is 0, 1, 2, 3, 4, or 5;
- x is 0 or 1;
- w is 0, 1 or 2;
- provided that if x is 0, then w is 0;
- and if w is 0, then x is 0;
- and
- *** indicates the point of attachment of A to B and ** indicates the point of attachment of B to A;
- and further provided that:
- (i) at least one of R8, R9, or R10:
- (a) is F, or (b) is a group that comprises at least one fluorine atom;
- or (ii) at least one R8 and R9, of a group of the formula —(CR8R9)—, —(CR8R9) or —(CR8R9R10), taken together forms a 3-, 4-, 5-, 6- or 7-membered carbocyclic or heterocyclic ring;
- or (iii) the compound of formula C-B is the hydroquinone form of a corresponding quinone that has a calculated Log D of 2 to 7, inclusive;
- or (iv) at least one R19 is R24C(O)—, R24OC(O)—, R24R25NC(O)—, or (R24O)(R25O)P(O)—.