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US 2024/0399001 A1Published application
Radiotracers and therapeutics binding to fibroblast activation protein (fap)
AssigneeBlue Earth Diagnostics Limited
InventorsSabitur RAHMAN, Romain BEJOT, Guyan LIANG, Abdul Karim HAJI, Colin BARNES
Life of this patent
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Abstract
The present invention relates to a ligand-SIFA conjugate, comprising, within in a single molecule two separate moieties: (a) one or more ligands which are capable of binding to Fibroblast Activation Protein (FAP), and (b) a silicon-fluoride acceptor (SI FA) moiety which comprises a covalent bond between a silicon atom and a fluorine atom.
Claims29
A ligand-SIFA conjugate, comprising, within in a single molecule two separate moieties:
- (a) one or more ligands which are capable of binding to Fibroblast Activation Protein (FAP), and
- (b) a silicon-fluoride acceptor (SIFA) moiety which comprises a covalent bond between a silicon and a fluorine atom and which SIFA is optionally labelled with 18F;
- or a pharmaceutically or diagnostically acceptable salt or solvate thereof.
Dependencies are inferred from the claim text.