Method for the early diagnosis of neurodegenerative diseases by means of quantification of prongf and derived forms thereof

Abstract

Method for the early diagnosis and the monitoring of the evolution/regression of neurodegenerative pathologies, said method providing for the quantification of a, biomarker for said pathologies in a fluid that was previously drawn from a, patient, said fluid being selected from among: cerebrospinal fluid; serum; urine; post mortem cerebral tissues and cellular lysates, said method being characterized in that the quantified biomarker is selected from among native proNGF; modified proNGF, the latter being proNGF in its forms with higher molecular weight, including forms of 39-40 kDa and 45-50 kDa; NGF; and the proNGF/NGF ratio, said method sequentially providing for the following steps of Preparation of the biological sample. Definition of the calibration curve: Execution of run and interpolation.

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