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US 2024/0393330 A1Published application
4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
AssigneeVisEn Medical, Inc.
InventorNarasimhachari Narayanan
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Abstract
The invention relates to a family of compounds that comprise fluorescent cyanine dyes. The compounds are near infrared absorbing heptamethine cyanine dyes with a 4,4-disubstituted cyclohexyl ring as part of the polymethine chromophore. The compounds are generally hydrophilic and can be chemically linked to biomolecules, such as proteins, nucleic acids, and therapeutic small molecules. The compounds can be used for imaging in a variety of medical, biological and diagnostic applications.
Claims18
A fluorescent compound represented by Formula I-A:
- or a salt thereof, wherein:
- X1 and X2 are each independently C(C1-4 alkyl)2;
- W1 and W2 are a benzo ring;
- R1 and R2 are independently —C1-C10 alkyl optionally substituted with one or two substituents independently selected from —SO3H and —SO3;
- R5, R6, R7, and R8 are each independently hydrogen or —C1-C22 alkylene-X3;
- R3, R4, R13 and R14 are each independently hydrogen, —SO3H, or —SO3−;
- X3 represents independently for each occurrence halogen, —CH3, —SO3H, —SO3−, —COOH, —CO2−, —NCS, —OH, maleimide, —NHCO—(CH2)m-(halogen), —CONHNH2, —CON(H)R12, alkynyl, —N3, or a polyethyl glycol;
- R9 and R10 are H;
- R12 represents independently for each occurrence hydrogen or alkyl;
- and
- m represents independently for each occurrence 0, 1, 2, 3, or 4.
8 more elements
Dependencies are inferred from the claim text.