Method for detecting and/or quantifying mood disorder and/or improvements of the mood disorder status using trigonelline as biomarker and improved methods and compositions thereof

Abstract

The present invention relates to the use of trigonelline as biomarker for detecting and/or quantifying improvements of the mood disorder status and/or excessive emotional reaction of a subject. It also relates to a method for detecting and/or quantifying mood disorder, improvements of the mood disorder status and/or excessive emotional reaction of a subject, in particular for monitoring the progress of an intervention to treat or ameliorate a mood disorder status and/or excessive emotional reaction in a subject, wherein the intervention comprises the administration of a probiotic. The method further comprises 4-cresol sulfate as additional biomarker. It also relates to an improved method to treat or ameliorate a mood disorder status and/or excessive emotional reaction in a subject in need, comprising administering to the subject, an effective amount of a composition combining a probiotic with trigonelline.

Dependencies are inferred from the claim text.