Enhanced chloride selective membrane
AssigneeSiemens Healthcare Diagnostics Inc.
InventorsBo Peng, David Thompson
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Abstract
There is provided a chloride selective membrane including an epoxide-based matrix reacted with a stoichiometric amount of an amino compound and an activator such that the epoxide-based matrix comprises a number of quaternary ammonium groups.
Claims20
A chloride selective membrane for a chloride selective electrode that detects chloride in multiple biological samples, wherein the chloride selective membrane is provided with a plurality of quaternary functional groups, and wherein the chloride selective membrane comprises:
- an epoxide-based matrix comprising an epoxy resin having a predetermined number of epoxide groups per molecule;
- a mixture of an amino compound and an activator dispensed onto a surface of the epoxide-based matrix, wherein the amino compound and activator are present in the mixture in a stoichiometric amount relative to the number of epoxide groups in the epoxide-based matrix, and wherein the stoichiometric amount is in a range of from about 0.5:1 to about 1.5:1, and wherein the mixture comprises reactive species;
- and
- wherein the chloride selective membrane is stable for at least 14 days upon exposure to at least one biological sample.
A process for forming a chloride selective membrane of a chloride selective electrode that detects chloride in at least one biological sample, the process comprising the steps of:
- forming a layer of an epoxide-based matrix, wherein the epoxide-based matrix comprises an epoxy resin having a predetermined number of epoxide groups per molecule;
- separately combining an amino compound and an activator to form a mixture and allowing the amino compound and the activator to react and produce reactive species prior to contact with the epoxide-based matrix, wherein the amino compound and activator are combined in a stoichiometric amount relative to the number of epoxide groups in the epoxide-based matrix, and wherein the stoichiometric amount is in a range of from about 0.5:1 to about 1.5:1;
- and
- dispensing the mixture containing the reactive species onto a surface of the epoxide-based matrix to form the chloride selective membrane, wherein the membrane is provided with a plurality of quaternary functional groups;
- and
- wherein the chloride selective membrane is stable for at least 14 days upon exposure to at least one biological sample.
Dependencies are inferred from the claim text.