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AssigneeShandong Agricultural University
InventorsKerong SHI, Xianpeng HOU, Tingjun LIU, Xiaoran YAN, Sisi FAN, Xuan ZHANG
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The present application belongs to the technical field of biology. Provided is exosome miRNA biomarkers in diagnosis and early warning of fatty liver in periparturient dairy cows. 12 miRNA biomarkers are discovered in the present application with diagnostic values in recognizing, early warning, identifying, and diagnosing fatty liver disease in dairy cows at corresponding disease stages, especially at least one of three of these miRNAs may be enriched without exosome extraction, and may be used to diagnose, in serum miRNA, whether the dairy cows is suffered from the disease.
At least one exosome miRNA shown in SEQ ID NO:
A reagent for testing an exosome miRNA in preparation of products for non-invasive recognition of fatty liver disease in periparturient dairy cows, wherein the exosome miRNA is at least one miRNA shown in SEQ ID NO:
A method for diagnosing the condition of a periparturient dairy cow, wherein the method comprises the following steps:
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