Rna therapeutics and methods of use thereof
AssigneeEli Lilly and Company
InventorsEllese CARMONA, Zhefeng LI, Christalyn Sims RHODES
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Abstract
ADAR activating RNA, RNA therapeutics comprising an ADAR activating RNA and methods of using same.
Claims24
An adenosine deaminase acting on RNA enzyme (ADAR) activating RNA (aRNA) that upregulates expression of ADAR, wherein the ADAR aRNA comprises an antisense oligonucleotide sequence, and wherein the target sequence is within SEQ ID NOs:
- 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 or 13.
(canceled)
An ADAR1p110 aRNA comprising an antisense oligonucleotide sequence given by one of SEQ ID NOs. 14-36 and 100-107.
An ADAR1p150 aRNA comprising an antisense oligonucleotide sequence given by one of SEQ ID NOs. 37-99, 108-113 and 134.
An ADAR2 aRNA comprising an antisense oligonucleotide sequence given by one of SEQ ID NOs. 114-133.
Dependencies are inferred from the claim text.