Modified protein disulfide isomerase and uses thereof
AssigneeThe University of North Carolina at Chapel Hill
InventorsBaggio Evangelista, Todd Cohen
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Abstract
Disclosed herein are modified protein disulfide isomerases (PDIs) or functional fragments thereof wherein the modified PDI or functional fragment thereof comprises a deletion of an endoplasmic reticulum (ER) signal sequence from a wild-type PDI or functional fragments thereof, and methods of making and using the same. The modified PDI or functional fragment thereof may be used to treat diseases associated with protein aggregates, including neurodegenerative diseases, muscular diseases, injuries, and aging-related conditions.
Claims29
A modified protein disulfide isomerase (PDI) or a functional fragment thereof, wherein the modified PDI or functional fragment thereof comprises a deletion of an N-terminal endoplasmic reticulum (ER) signal sequence from a wild-type PDI or functional fragment thereof, wherein the PDI is not P4HB.
A modified protein disulfide isomerase (PDI) or a functional fragment thereof, wherein the modified PDI or functional fragment thereof comprises a deletion of a C-terminal endoplasmic reticulum (ER) signal sequence from a wild-type PDI or functional fragment thereof.
A modified protein disulfide isomerase (PDI) or a functional fragment thereof, wherein the modified PDI or functional fragment thereof comprises a deletion of an endoplasmic reticulum (ER) signal sequence from a wild-type PDI or functional fragment thereof and further comprises a nuclear localization signal (NLS).
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Dependencies are inferred from the claim text.