Anti-lag3 bispecific antibody, pharmaceutical composition and use

Abstract

Provided are an anti-LAG3 antibody bispecific antibody, a pharmaceutical composition thereof and a use thereof, which belong to the field of biomedicine. Specifically, the bispecific antibody comprises a first protein functional domain and a second protein functional domain, wherein the first protein functional domain targets LAG3, and the second protein functional domain targets a target that is different from LAG3, the first protein functional domain is an anti-LAG3 antibody or an antigen-binding fragment thereof and contains a heavy chain variable region and a light chain variable region, the heavy chain variable region contains HCDR1-HCDR3 the amino acid sequences of which are respectively represented by SEQ ID NOs: 5-7. In addition, the light chain variable region contains LCDR1-LCDR3 the amino acid sequences of which are respectively represented by SEQ ID NOs: 8-10. The bispecific antibody has excellent affinity and specificity, and has good application prospects.

Dependencies are inferred from the claim text.