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US 2024/0391941 A1Published application
Naphthyridinone derivatives for the treatment of a disease or disorder
AssigneeNovartis AG
InventorsAtwood CHEUNG, Donglei LIU, Stefan PEUKERT, John TRAUGER
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Abstract
The present disclosure relates to a compound which is a phosphoric acid ester derivative of a compound of formula (I): wherein A, L and R3 are as described herein, as well as compositions and methods of using such compound.
Claims19
A compound which is a phosphoric acid ester derivative of a compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein
- L is (C1-C6) alkylene optionally substituted with one or more —OH;
- A is —OR2 or (C1-C6) alkyl optionally substituted with one or more substituents independently selected from —SO2(C1-C4)alkyl, —NHC(O)Rb, and —C(O)NHRc;
- R2 is (C1-C6) alkyl substituted with one or more substituents independently selected from —NHC(O)Rd and —C(O)NHRe, wherein the (C1-C6)alkyl is optionally further substituted with one or more substituents independently selected from halogen, —OH and —CN;
- Ra, Rb, Rc, Rd, and Re are each independently selected from H and (C1-C6) alkyl optionally substituted with one or more —OH;
- and
- R3 is (C1-C4)alkyl.
4 more elements
Dependencies are inferred from the claim text.