Compounds and Compositions for the Treatment of Cancer, Retinal Disorders, and Cardiomyopathies
AssigneesFondazione Istituto Italiano Di Tecnologia, The Regents of the University of California
InventorsMarco De Vivo, Anand Ganesan, Jose Antonio Ortega Martinez, Sohail Jahid
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.
Claims12
A compound of formula (I):
- or pharmaceutically acceptable salts or solvates thereof wherein:
- X1 and X2 are independently selected from the group consisting of CH2, NR2 and O provided that X1 and X2 are not both NR2, both O or NR2 and O at the same time;
- Y is selected from the group consisting of CH and N;
- A and A′ are independently selected from the group consisting of a 6-membered heteroaromatic ring that contains 1 or 2 nitrogen atoms and a 6-membered aromatic ring optionally substituted at any position with a substituent selected from the group consisting of C1-6alkyl, halogen, halo-C1-6alkyl, hydroxyl, alkoxy-C1-6alkyl, amino, amino-C1-6alkyl and amino-diC1-6alkyl;
- R1 is selected from the group consisting of hydrogen and C1-6alkyl;
- R2 is selected from the group consisting of hydrogen, C1-6alkyl, C1-6alkyl-alkoxy, CO—C1-6alkyl and CO—C1-6alkyl-alkoxy. any position with a substituent selected from the group consisting of halogen, alkoxy-C1-6alkyl, amino, amino-C1-6alkyl and amino-diC1-6alkyl;
- R1 is hydrogen;
- R2 is hydrogen.
A compound according to claim characterized in that X1 is selected from the group consisting of CH2, NH and O;
- X2 is selected from the group consisting of CH2 and NH provided that X1 and X2 are not N at the same time;
- Y is CH2;
- A is selected from the group consisting of 6-membered heteroaromatic ring that contains 1 nitrogen atom in position 2 or 3 and a 6-membered aromatic ring optionally substituted with a substituent selected from the group consisting of halogen and alkoxy-C1-3alkyl;
- A′ is selected from the group consisting of 6-membered aromatic ring optionally substituted in meta or para positions with a substituent selected from the group consisting of halogen, alkoxy-C1-6alkyl and amino-diC1-6alkyl;
- R1 is hydrogen;
- R2 is hydrogen.
Dependencies are inferred from the claim text.