Salts of Obicetrapib and Processes for their Manufacture and Intermediates Thereof
AssigneeNewAmsterdam Pharma B.V.
InventorsSheng CUI, Andreas René RÖTHELI, Christopher J. BORTHS, Muneki KISHIDA, Valeriya Nikolayevna SMOLENSKAYA
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Abstract
Provided herein is a method for the manufacture of a compound of obicetrapib and salts thereof, such as calcium salts thereof. Also provided herein is amorphous obicetrapib hemicalcium. New intermediates for use in the synthesis of obicetrapib, and salts thereof are also provided, including obicetrapib HCl and a mesylate salt for the use in the synthesis of obicetrapib and amorphous obicetrapib hemicalcium.
Claims22
Crystalline obicetrapib hydrochloride.
Form A crystalline obicetrapib hydrochloride.
Form B crystalline obicetrapib hydrochloride.
Form C crystalline obicetrapib hydrochloride.
Form D crystalline obicetrapib hydrochloride.
Dependencies are inferred from the claim text.