Antimicrobial compounds and the methods of use
AssigneeMiddle Tennessee State University
InventorsKevin Lee Bicker, Robert Madison Green
Life of this patent
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Abstract
Peptoids, compositions thereof, and methods of using the peptoids. The peptoid may be an antimicrobial peptoid. In some embodiments, the peptoid may be used to treat or prevent a fungal infection, a biofilm produced from a fungal infection, or a combination thereof, in a vertebrate, such as a human or an animal, or in a plant. In some embodiments, the peptoid may be used to treat or prevent a bacterial infection, or biofilm produced from a bacterial infection, or a combination thereof, in a vertebrate, such as a human or an animal, or in a plant.
Claims28
A compound of the general formula,
- a protonated form thereof, a pharmaceutically acceptable salt thereof, or both,
- wherein:
- AX is H or a linear or branched (C6 to C20)alkyl or a linear or branched (C6 to C20)alkenyl, wherein the alkyl or the alkenyl optionally includes a carbonyl group;
- T is a linear or branched (C6 to C20)alkyl or a linear or branched (C6 to C20)alkenyl, wherein the alkyl or the alkenyl optionally includes a carbonyl group;
- Q is a hydroxyl or NH2;
- and
- R1, R2, R3, R4, R5, and R6 are each independently
- or an alkyl amine of the general formula R10NR11R12R13,
- wherein:
- each n is independently (C0 to C3)alkylene;
- each y is independently (C0 to C6)alkylene;
- for each R1, R2, R3, R4, R5, and/or R6 that is NcpenW, each W is independently N, S, or O;
- for each R1, R2, R3, R4, R5, and/or R6 that is NlinW, each W is independently N, S, or O;
- for each R1, R2, R3, R4, R5, and/or R6 that is NphX, each X is independently F, Cl, Br, or I;
- for each R1, R2, R3, R4, R5, and/or R6 that is NpenZ, each Z is independently S, or O;
- for each R1, R2, R3, R4, R5, and/or R6 that is R10NR11R12R13, each R10 is independently a linear (C1-C6)alkylene;
- for each R1, R2, R3, R4, R5, and/or R6 that is NnphOR, each R50 is independently (C1 to C3)alkyl;
- and
- for each R1, R2, R3, R4, R5, and/or R6 that is R10NR11R12R13, each R11, each R12, and each R13 are independently H or (C1 to C6)alkyl.
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A composition comprising:
- a compound of the general formula,
- or a protonated form thereof, wherein:
- AX is H or a linear or branched (C6 to C20)alkyl or a linear or branched (C6 to C20)alkenyl, wherein the alkyl or the alkenyl optionally includes a carbonyl group;
- T is a linear or branched (C6 to C20)alkyl or a linear or branched (C6 to C20)alkenyl, wherein the alkyl or the alkenyl optionally includes a carbonyl group;
- Q is a hydroxyl or NH2;
- and
- R1, R2, R3, R4, R5, and R6 are each independently
- or an alkyl amine of the general formula R10NR11R12R13,
- wherein:
- each n is independently (C0-C3)alkylene;
- each y is independently (C0-C6)alkylene;
- for each R1, R2, R3, R4, R5, and/or R6 that is NcpenW, each W is independently N, S, or O;
- for each R1, R2, R3, R4, R5, and/or R6 that is NlinW, each W is independently N, S, or O;
- for each R1, R2, R3, R4, R5, and/or R6 that is NphX, each X is independently F, Cl, Br, or I;
- for each R1, R2, R3, R4, R5, and/or R6 that is NpenZ, each Z is independently S, or O;
- for each R1, R2, R3, R4, R5, and/or R6 that is R10NR11R12R13, each R10 is independently a linear (C1-C6)alkylene;
- for each R1, R2, R3, R4, R5, and/or R6 that is NnphOR, each R50 is independently (C1 to C3)alkyl;
- and
- for each R1, R2, R3, R4, R5, and/or R6 that is R10NR11R12R13, each R11, each R12, and each R13 are independently H or (C1 to C6)alkyl;
- and
- a pharmaceutically acceptable carrier or fungicidal acceptable carrier.
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19-20. (canceled)
22-23. (canceled)
25-27. (canceled)
30-32. (canceled)
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Dependencies are inferred from the claim text.