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US 2024/0391880 A1Published application
KCa3.1 INHIBITORS FOR PODOCYTE PROTECTION
AssigneesIcahn School of Medicine at Mount Sinai, Long Island University
InventorsKirk CAMPBELL, Bhaskar DAS, Jenny WONG
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Abstract
The present disclosure relates to compounds of Formula I and II and pharmaceutically acceptable salts thereof: and a pharmaceutical composition including a compound of formula I or II and a pharmaceutically acceptable excipient. Also provided is a method of administering a compound of formula I or II or a physiological salt thereof, or said pharmaceutical composition to a subject, wherein the subject suffers from kidney disease or is at risk of kidney disease.
Claims22
A compound of Formula I:
- or a pharmaceutically acceptable salt thereof, wherein
- X1 is selected from N, O, and S;
- R1, R2, R3, and R4 are each independently selected from hydrogen, halogen, CN, C(═O)N(R6)2, C(═O)OR6, (C3-C10)carbocycle, heterocycle, and B(OH)2;
- R5 is selected from (C3-C10)carbocycle and heterocycle, wherein each is optionally substituted with one or more of halogen, CN, C(═O)N (R6)2, C(═O)OR6, (C3-C10)carbocycle, heterocycle, or B(OH)2;
- and
- R6 in each occurrence is independently selected from hydrogen and (C1-C6)alkyl.
3 more elements
A compound of Formula II:
- or a pharmaceutically acceptable salt thereof, wherein
- X2 is selected from N, O, and S;
- R10, R11, R12, and R13 are each independently selected from hydrogen, halogen, CN, C(═O)N(R15)2, C(═O)OR15, C(═O)R15, —N(R15)2, (C1-C6)alkoxy, (C1-C6)thiaalkyl, (C1-C6)oxaalkyl, oxo(C1-C6)azaalkene, (C3-C10)carbocycle, heterocycle, and B(OH)2, wherein said heterocycle is optionally substituted with one or more of —N(R15)2, wherein R15 in each occurrence is independently selected from hydrogen and (C1-C6)alkyl;
- and
- R14 is selected from (C3-C10)carbocycle and heterocycle, wherein each is optionally substituted with one or more of halogen, CN, C(═O)N(R15)2, C(═O)OR15, C(═O)R15, (C1-C6)alkoxy, (C1-C6)thiaalkyl, (C1-C6)oxaalkyl, oxo(C1-C6) azaalkene, —N(R15)2, (C3-C10)carbocycle, heterocycle, B(OH)2, and —N(R15)2.
2 more elements
19-24. (canceled)
27-30. (canceled)
Dependencies are inferred from the claim text.