Novel, safe, economical and an efficient process for preparation of 3-fluoro-2-nitro pyridine of formula i

A process for the preparation of 3-fluoro-2-nitro pyridine of formula I

• comprising:
• a. Diazotization of 3-amino-2-nitropyridine of formula III with sodium nitrite in presence of fluoroboric acid as represented herein below to afford a compound of Formula II;
• ii. isolation of the compound of formula II from the reaction mass of step I;
• iii. decomposition of compound of formula II obtained in step ii comprising its lot wise addition in to a solvent resulting into formation of compound of formula I;
• iv. maintaining refluxing till the completion of the reaction;
• v. removal of solvent from the reaction mass followed by degassing the reaction mass;
• vi. distillation under reduced pressure to obtain desired product 3-fluoro-2-nitro pyridine of formula I;
• vii. purification of 3-fluoro-2-nitro pyridine of formula I obtained from stage vi using suitable solvent to obtain pure 3-fluoro-2-nitro pyridine with high purity 98.67%.