Apparatus, systems and methods for transdermal drug delivery, permeability enhancement and augmentation
AssigneeUniversity of Iowa Research Foundation
InventorsNicole Brogden, Krishna Kumar Patel
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Abstract
The disclosed apparatus, systems and methods relate to a permeation enhancing transdermal patch for the administration of a therapeutic compound transdermally. A transdermal patch for the administration of a therapeutic compound to a subject that has a microneedle layer with microneedles made of naloxone and a binder, an active layer with naloxone and a carrier and an augmentation layer configured to generate local heat on the skin of the subject. The patch can omit the microneedle layer or augmentation layer.
Claims21
1-47. (canceled)
A transdermal patch for administration of naloxone to a subject in need thereof, comprising:
- a) a dissolving microneedle layer;
- b) an active layer;
- and
- c) an augmentation layer.
A transdermal patch for the administration of naloxone to a subject, comprising:
- a) a microneedle layer comprising microneedles comprising naloxone and a binder;
- b) an active layer comprising naloxone and a carrier;
- and
- c) an augmentation layer configured to generate local heat on skin of the subject.
A method for administering a therapeutic compound to a subject, comprising:
- applying a transdermal patch to the skin of a subject, wherein the transdermal patch comprises:
- a) a microneedle layer comprising microneedles comprising the therapeutic compound;
- and
- b) an augmentation layer configured to generate local heat on skin of the subject continuing the application of the transdermal patch for an administration time.
Dependencies are inferred from the claim text.