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US 2024/0390510 A1Published application
Compositions of protein complexes and methods of use thereof
AssigneeBonum Therapeutics, Inc.
InventorsJohn Thomas MULLIGAN, Shannon Lee OKADA, Justin Richard KILLEBREW, Diane Louise HOLLENBAUGH
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Abstract
Provided herein are protein complexes comprising a sensor domain and a therapeutic domain linked by a linker, and methods of use thereof. In aspects of the present disclosure, activity of the therapeutic domain comprises a dependence on sensor domain binding to target markers.
Claims24
A complex comprising:
- (a) a therapeutic domain;
- and
- (b) a sensor domain that is a dual-binding antibody or antigen-binding fragment thereof, wherein the sensor domain comprises a heavy chain variable domain and a light chain variable domain, wherein the heavy chain variable domain and the light chain variable domain are present in an IgG isotype antibody or a single chain variable fragment (scFv), wherein the sensor domain is linked to the therapeutic domain by a flexible linker;
- wherein the sensor domain binds:
- (i) the therapeutic domain;
- and (ii) a marker, but not both simultaneously, wherein:
- (i) when the sensor domain is bound to the therapeutic domain, the therapeutic domain is blocked from binding to its receptor;
- and
- (ii) when the sensor domain is bound to the marker, the sensor domain is blocked from binding the therapeutic domain and the therapeutic domain is capable of binding to its receptor.
6 more elements
Dependencies are inferred from the claim text.