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US 2024/0390490 A1Published application
Pharmaceutical compositions for the treatment of cancers
AssigneeRutgers, The State University of New Jersey
InventorDipak K. SARKAR
Life of this patent
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Abstract
The present application relates to pharmaceutical compositions and to the use of such compositions in the treatment of certain cancers, wherein such compositions positively affect the stress axis and immune system in patients in need of treatment.
Claims35
A pharmaceutical combination, comprising:
- a. at least one MU (μ) opioid receptor (MOR) antagonist;
- b. at least one BETA (β) 2-adrenergic receptor (B2AR) antagonist;
- c. at least one compound selected from the group consisting of:
- a. a DELTA (Δ) opioid receptor (DOR) agonist;
- and
- b. an immune checkpoint inhibitor (ICI);
- and
- d. at least one pharmaceutically acceptable carrier or diluent.
5 more elements
32-41. (canceled)
A method of treatment for affecting the growth and progression of a cancer in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a pharmaceutical combination, the combination comprising:
- a. at least one MU (μ) opioid receptor (MOR) antagonist;
- b. at least one BETA (β) 2-adrenergic receptor (B2AR) antagonist;
- c. at least one compound selected from the group consisting of:
- i. a DELTA (Δ) opioid receptor (DOR) agonist;
- and
- ii. an immune checkpoint inhibitor (ICI);
- and
- d. at least one pharmaceutically acceptable carrier or diluent.
5 more elements
Dependencies are inferred from the claim text.