US 2024/0390485 A1 · HYPOALLERGENIC PEANUT ALLERGENS, PRODUCTION AND USE THEREOF

Abstract

In one embodiment, the present disclosure provides hypoallergenic peanut allergens Ara h 1 or Ara h 2 variants lacking at least one epitope recognized by anti-Ara h 1 antibodies or anti-Ara h 2 antibodies, thereby having reduced or abolished antibody binding to the peanut allergen variants. These hypoallergenic peanut allergen variants may be used in methods of inducing desensitization to peanuts in a subject allergic to peanuts.

Claims37

Dependent claims

A recombinant Ara h 2 variant polypeptide comprising one or more substitutions, deletions, insertions, or any combination thereof, that are located at one or more of positions 12, 15, 16, 22, 24, 46, 53, 65, 80, 83, 86, 87, 90, 104, 115, 123, 127, or 140 of SEQ ID NO:

4, as compared with the amino acid residues at those same positions in SEQ ID NO:
3, wherein the variant polypeptide is at least 80% identical to the sequence set forth in SEQ ID NO:
3.

A recombinant Ara h 1 variant polypeptide comprising one or more amino acid substitutions, deletions, insertions, or any combination thereof, that are located at one or more of positions 194, 195, 213, 215, 231, 234, 245, 267, 287, 294, 312, 331, 419, 422, 443, 455, 462, 463, 464, 480, 494, or 500 of SEQ ID NO:

67, as compared with the amino acid residues at those same positions in SEQ ID NO:
65, wherein the variant polypeptide is at least 80% identical to the sequence set forth in SEQ ID NO:
65.

Dependencies are inferred from the claim text.

Hypoallergenic peanut allergens, production and use thereof

Life of this patent

Hypoallergenic peanut allergens, production and use thereof

Life of this patent

Abstract

Claims37