Compositions and methods for therapeutic or vaccine delivery
AssigneeGenVivo, Inc.
InventorsJacqueline FISCHER-LOUGHEED, Bradford H. STEELE, Cecilia ROH, Robert G. JOHNSON, JR.
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Abstract
Described herein are compositions comprising recombinant viral vectors, e.g., recombinant retroviral vectors, for delivering a therapeutic or a vaccine. The recombinant retroviral vectors described herein are modified for safer application of therapeutic or vaccine delivery. Also described herein are methods for using the compositions comprising recombinant viral vectors for delivering a therapeutic or a vaccine.
Claims21
1-80. (canceled)
A method of treating or preventing a disease or condition in a subject, comprising administering to the subject a recombinant retroviral vector comprising a first nucleic acid sequence having a deleted integrase and a second nucleic acid sequence encoding at least one payload, wherein the recombinant retroviral vector has defective retroviral integration activity as compared to a recombinant retroviral vector comprising a wild-type integrase, wherein the at least one payload comprising the antigen induces an immune response in the subject, thereby treating or preventing the disease or condition in the subject.
Dependencies are inferred from the claim text.