Targeted traditional chinese medicine in-situ tumor vaccine, and preparation method and application thereof

Abstract

Disclosed are a targeted traditional Chinese medicine in-situ tumor vaccine, a preparation method thereof and an application thereof in resisting pancreatic cancer. In the invention, PLGA nanospheres are used to carry Lycium barbarum polysaccharide and Brusatol, and subjected to surface modification with a macrophage membrane and a c-RGD peptide. The invention can be targeted at a tumor site in vivo, so that the tumor undergoes immunogenic cell death and releases tumor antigens, and can also regulate immune cells at the same time, so as to remodel the tumor microenvironment, and achieve robust anti-pancreatic cancer effect. In the invention, the preparation method is simple, and the tumor vaccine is suitable for carrying a cancer therapeutic drug, especially a drug for treating pancreatic cancer.

Dependencies are inferred from the claim text.