Anti-trem2 chimeric antigen receptor

The CAR according to any preceding claim wherein the antigen recognition domain comprises:

• (i) VH CDR1, 2 and 3 sequences as set forth in SEQ ID NOs:
• 1, 2 and 3 respectively and VL CDR1, 2 and 3 sequences as set forth in SEQ ID NOs:
• 4, 5 and 6 respectively,
• (ii) VH CDR1, 2 and 3 sequences as set forth in SEQ ID NOs:
• 7, 8 and 9 respectively and VL CDR1, 2 and 3 sequences as set forth in SEQ ID NOs:
• 10, 11 and 12 respectively,
• (iii) VH CDR1, 2 and 3 sequences as set forth in SEQ ID NOs:
• 13, 14 and 15 respectively and VL CDR1, 2 and 3 sequences as set forth in SEQ ID NOs:
• 16, 17 and 18 respectively, or
• (iv) VH CDR1, 2 and 3 sequences as set forth in SEQ ID NOs:
• 19, 20 and 21 respectively and VL CDR1, 2 and 3 sequences as set forth in SEQ ID NOs:
• 22, 23 and 24 respectively,
• wherein one or more of said CDR sequences of (i)-(iv) may optionally comprise 1 to 3 amino acid modifications relative to an aforementioned CDR sequence, particularly wherein one or more of said CDR sequences may optionally be modified by substitution, addition or deletion of 1 to 3 amino acids.