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US 2024/0390380 A1Published application
Laureth-4 containing topical formulations
AssigneeArcutis Biotherapeutics, Inc.
InventorDavid W. OSBORNE
Life of this patent
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Abstract
The present invention is a method and composition comprising laureth-4 in topical formulations, wherein the laureth-4 increases the penetration of active ingredients across the skin. In a particularly preferred embodiment, the active ingredient is SHR0302.
Claims20
A topical pharmaceutical composition comprising SHR0302, laureth-4, and a solvent.
A method of treating an inflammatory skin disease, disorder, or condition in a subject in need thereof, comprising:
- topically administering to the subject a pharmaceutical composition comprising SHR0302, laureth-4, and a solvent.
A method for enhancing the skin penetration in a human subject of a topical pharmaceutical formulation comprising:
- preparing a formulation comprising SHR0302, laureth-4 and a solvent,
- wherein the skin penetration of the topical pharmaceutical composition is enhanced by 5-fold to 30-fold relative to the same topical pharmaceutical formulation without laureth-4 in the subject.
Dependencies are inferred from the claim text.