Mocetinostat in combination with chemotherapy to treat rhabdomyosarcoma
AssigneeThe Regents of the University of California
InventorsArun Sayram SINGH, Noah FEDERMAN, Dennis Joseph SLAMON, Neil O'BRIEN
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Abstract
The present disclosure provides a method of using mocetinostat in combination with vinorelbine to treating a patient with rhabdomyosarcoma (RMS). The patient can be a child, an adolescent, or an adult having a locally advanced RMS, an unresectable RMS, a metastatic RMS, or a recurrent RMS.
Claims29
A method of treating a subject having rhabdomyosarcoma (RMS), comprising the steps of administering mocetinostat to the subject, and administering vinorelbine to the subject.
A therapeutic combination for treating rhabdomyosarcoma (RMS), comprising a therapeutically effective amount of mocetinostat and a therapeutically effective amount of vinorelbine.
A method of treating a subject having rhabdomyosarcoma (RMS), comprising the steps of administering a HDAC inhibitor to the subject, and administering a vinca alkaloid to the subject.
A therapeutic combination for treating rhabdomyosarcoma (RMS), comprising a therapeutically effective amount of a HDAC inhibitor and a therapeutically effective amount of a vinca alkaloid.
Dependencies are inferred from the claim text.