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US 2024/0390344 A1Published application
Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluoropheyl)-3-phenylurea
AssigneeDeciphera Pharmaceuticals, LLC
InventorsMichael D. Kaufman, Scott Bone, Corey Bloom, Fred Jordan
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Abstract
Provided herein are low impurity compositions comprising a compound represented by Formula (I): which are useful in the treatment of disorders related to the activity of the c-KIT and PDGFRα kinases, and oncogenic forms thereof.
Claims13
A pharmaceutical composition comprising:
- a solid dispersion comprising:
- a compound represented by Formula (I) or pharmaceutically acceptable salt thereof,
- and a pharmaceutically acceptable polymer;
- and
- one or more anilinic substances, wherein the one or more anilinic substances, is present in an amount equal to or less than about 10% by weight based on the weight of the compound of Formula (I) present in the composition,
- and wherein water is present in the composition in an amount of no more than about 6% by weight based on the total weight of the pharmaceutical composition.
3 more elements
Dependencies are inferred from the claim text.