Iso-osmotic and near iso-osmotic oxygen therapeutic formulations and methods thereof
AssigneeNuvOx Pharma LLC
InventorsEvan C. Unger, Edmund R. Marinelli
Life of this patent
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Abstract
The invention provides novel iso-osmotic or near iso-osmotic formulations of fluorocarbon emulsions that are useful as oxygen therapeutics, for example, for treating sickle cell disease and related diseases and conditions, as well as methods of preparation and use thereof.
Claims12
1-65. (canceled)
An oxygen therapeutic composition, comprising:
- a fluorocarbon compound selected from the group consisting of perfluorobutane, perfluoropentane and perfluorohexane;
- PEG-Telomer B (PTB) as a surfactant;
- a viscogen at a concentration between about 2 w/v % to about 15 w/v % selected from
- polyethylene glycol (PEG) with average molecular weight Mn between about 200 and about 400, and
- maltitol;
- and
- water,
- wherein the oxygen therapeutic composition
- is an emulsion of particles comprising the fluorocarbon and having particle sizes:
- intensity weighted mean diameter (IWMD) in the range from about 100 nm to about 600 nm, and
- is characterized by an osmolality in the range from about 275 milliosmoles/kg to about 305 milliosmoles/kg.
An oxygen therapeutic composition, comprising:
- a fluorocarbon compound selected from the group consisting of perfluorobutane, perfluoropentane and perfluorohexan;
- PEG-Telomer B (PTB) as a surfactant;
- and
- NaCl in a concentration from about 0.7% w/v to about 1.2% w/v, wherein the oxygen therapeutic composition
- is an emulsion of particles comprising the fluorocarbon and having particle sizes:
- intensity weighted mean diameter (IWMD) in the range from about 100 nm to about 600 nm, and
- is characterized by an osmolality in the range from about 275 milliosmoles/kg to about 305 milliosmoles/kg,
- wherein the composition is free of a viscogen and is free of sucrose.
A method for treating sickle cell disease, or a related disease or condition, comprising administering to a subject in need thereof an oxygen therapeutic composition comprising:
- a fluorocarbon compound comprising about 4 to about 8 carbon atoms, a surfactant, a viscogen and water, wherein the oxygen therapeutic composition is characterized by an osmolality in the range from about 200 milliosmoles/kg to about 500 milliosmoles/kg.
A method for treating sickle cell disease, or a related disease or condition, comprising administering to a subject in need thereof an oxygen therapeutic composition comprising:
- a fluorocarbon compound comprising about 4 to about 8 carbon atoms;
- a surfactant;
- and
- saline in a concentration from about 0.6% w/v to about 1.5% w/v, wherein the oxygen therapeutic composition
- is an emulsion of particles comprising the fluorocarbon, and
- is characterized by an osmolality in the range from about 200 milliosmoles/kg to about 500 milliosmoles/kg.
Dependencies are inferred from the claim text.