Lipocoacervates and methods of making and using same

Abstract

Lipocoacervates and compositions comprising lipocoacervates, methods of making and using same. A lipocoacervate comprises a coacervate phase and a lipid or lipids, where the lipid(s) is/are disposed on at least a portion of an exterior surface of the coacervate phase, and optionally, one or more biomolecules. In various examples, a coacervate phase comprises cationic component(s), such as, for example, polycations, such as, for example, chitosan, spermine, spermidine, positively-charged polymers, positively-charged proteins, and any combination thereof, and anionic component(s), such as, for example, polyanions, such as, for example, glycosaminoglycans, nucleic acids, negatively-charged proteins, and any combination thereof. In various examples, an anionic component is a biomolecule. In various examples, a lipocoacervate is made by contacting a coacervate composition with a lipid composition, where lipocoacervate(s) or a lipocoacervate composition is/are formed. In various examples, lipocoacervates or lipocoacervate composition(s) is/are used to intracellularly deliver a biomolecule or biomolecules to an individual.

Dependencies are inferred from the claim text.