Bipolar Pulsed High Voltage Electric Field Treatment

A bipolar high voltage tissue treatment system comprising:

• a pulsed electric field device comprising:
• an elongate body;
• and
• an expandable member comprising a compressed configuration, an expanded configuration, an electrode for ablation or electroporation, and a fluid opening, wherein, in the expanded configuration, the expandable is configured to dilate tissue and to apply suction to the tissue via the fluid opening of the expandable member;
• and
• a power supply configured to deliver a pulse waveform to the electrode to generate a pulsed or modulated electric field to treat the tissue, wherein the power supply is adapted to produce high voltage bipolar pulses with a positive high voltage pulse greater than about 200 V followed by a negative high voltage pulse less than about −200 V.

A bipolar high voltage treatment system comprising a power supply, the power supply comprising:

• a first DC source;
• a first energy storage capacitor coupled with the first DC source;
• a first diode having an anode and a cathode, the anode electrically coupled with the first DC source and the first energy storage capacitor;
• a first high voltage switch electrically coupled with the cathode of the first diode;
• a first diode arranged across the first high voltage switch;
• a second high voltage switch electrically coupled with the cathode of the first diode;
• a second diode arranged across the second high voltage switch;
• a third high voltage switch arranged in series between the first high voltage switch and ground;
• a third diode arranged across the third high voltage switch;
• a fourth high voltage switch arranged in series between the second high voltage switch and ground;
• a fourth diode arranged across the fourth high voltage switch;
• a second DC source;
• a second energy storage capacitor coupled with the second DC source;
• a fifth high voltage switch electrically coupled with the second DC source and the second energy storage capacitor;
• a fifth diode arranged across the fifth high voltage switch;
• a sixth high voltage switch electrically coupled with the cathode of the second DC source and the second energy storage capacitor;
• a sixth diode arranged across the sixth high voltage switch;
• and
• an output having a first lead electrically coupled between first high voltage switch and the third high voltage switch and the second lead electrically coupled between second high voltage switch and the fourth high voltage switch.