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US 2024/0375114 A1Published application
Biological sample holder and handler
AssigneeQcdx LLC
InventorsTriantafyllos P. Tafas, Seth Winfree, Scott W. Reed
Life of this patent
Estimating the term…
Abstract
The present invention provides a biological sample holder and handler system for cell-based liquid biopsies. The system is useful for performing diagnostic assays, based on a simple blood sample. For example, the system is useful for delivering precision cancer diagnoses that improve patient outcomes by optimizing treatment options, monitoring therapy efficacy, characterizing metastasis and assessing treatment toxicity
Claims18
-37. (canceled)
A device comprising:
- (a) a chamber configured to receive a container, wherein the container holds a biological sample, and wherein the chamber comprises:
- (i) a first end configured to receive at least a portion of the container, wherein the first end is operably coupled to a fluid input port;
- (ii) a second end;
- and
- (iii) an interior wall connecting the first end and the second end, wherein the interior wall comprises:
- (1) a first portion disposed between the first end and the second end, wherein the first portion is configured to permit directing of a light towards the biological sample when the biological sample is disposed within the chamber;
- and
- (2) a second portion disposed between the first end and the second end, wherein the second portion is configured to permit detection, by a detector, of the biological sample when the biological sample is exposed to the light;
- (b) an optical source coupled to the chamber and positioned at the first portion of the interior wall, wherein the optical source is configured to direct the light through the first portion and towards the biological sample;
- and
- (c) the detector, wherein the detector is coupled to the chamber and positioned at the second portion of the interior wall, and wherein the detector is configured to detect the biological sample through the second portion upon the exposure to the light.
8 more elements
A system comprising:
- a container configured to hold a biological sample;
- and
- a device operatively coupled to the container, wherein the device comprises:
- (a) a chamber configured to receive the container when the container is holding the biological sample, wherein the chamber comprises:
- (i) a first end configured to receive at least a portion of the container, wherein the first end is operably coupled to a fluid input port;
- (ii) a second end;
- and
- (iii) an interior wall connecting the first end and the second end, wherein the interior wall comprises:
- (1) a first portion disposed between the first end and the second end, wherein the first portion is configured to permit directing of a light towards the biological sample, wherein the biological sample is disposed within the chamber;
- and
- (2) a second portion disposed between the first end and the second end, wherein the second portion is configured to permit detection, by a detector, of the biological sample when the biological sample is exposed to the light;
- (b) an optical source coupled to the chamber and positioned at the first portion of the interior wall, wherein the optical source is configured to direct the light through the first portion and towards the biological sample;
- and
- (c) the detector, wherein the detector is coupled to the chamber and positioned at the second portion of the interior wall, and wherein the detector is configured to detect the biological sample through the second portion upon exposure to the light.
11 more elements
Dependencies are inferred from the claim text.