Bioactive molecules for use in treating insulin resistance and/or restoring glucose homeostasis
AssigneePaltech
InventorsCharles-Henri MALBERT, Maurice Reginald ALLOUCHE
Life of this patent
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Abstract
The present invention relates to a bioactive molecule upregulating GLP-1r for use in treating insulin resistance and/or restoring glucose homeostasis by local administration to the peri-portal region of the portal vein.
Claims27
Bioactive molecule upregulating GLP-1r for use in treating insulin resistance and/or restoring glucose homeostasis by local administration to the peri-portal region of the portal vein.
Bioactive molecule upregulating GLP-1r for use in treating insulin resistance and/or restoring glucose homeostasis, wherein said bioactive molecule is administered, the peri-portal region, at a dose that is at least about 10-fold inferior to the ED50 of said bioactive molecule, preferably at a dose that is from 10-fold inferior to 100-fold inferior to the ED50 of the molecule.
A method of treating insulin resistance and/or restoring glucose homeostasis in a subject in need thereof, comprising the steps of:
- a. providing at least one bioactive molecule upregulating the expression of GLP-1r, and
- b. locally administering said at least one bioactive molecule to the peri-portal region of the portal vein.
A method of treating insulin resistance and/or restoring glucose homeostasis in a subject in need thereof, comprising the steps of:
- a. providing at least one bioactive molecule upregulating the expression of GLP-1r, and
- administering said at least one bioactive molecule to the peri-portal region of the portal vein,
- wherein the bioactive molecule is administered at a dose that is at least about 10-fold inferior to the ED50 of said bioactive molecule, preferably at a dose that is from 10-fold inferior to 100-fold inferior to the ED50 of the molecule.
Dependencies are inferred from the claim text.