Method for diagnosis of lung disease based on antibodies for microbial-derived vesicles
AssigneeMd Healthcare Inc.
InventorYoon-Keun Kim
Life of this patent
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Abstract
The present invention relates to a method for diagnosing a lung disease based on antibodies against microorganism-derived vesicles and, more particularly, to a method for diagnosing a lung disease by performing bacterial metagenome analysis using samples derived from a subject to analyze an increase or decrease in IgG, IgG1 and/or IgG4 levels in extracellular vesicles derived from specific bacteria.
Claims20
A method for diagnosing a lung disease or predicting a risk for a lung disease, the method comprising the following steps:
- (a) obtaining a sample from a subject;
- (b) measuring protein levels using antibodies against one or more proteins selected from the group consisting of extracellular vesicle IgG, extracellular vesicle IgG1 and extracellular vesicle IgG4 for the obtained sample;
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- (c) comparing the protein levels with those of a control.
A kit for diagnosing a lung disease comprising a composition for diagnosing a lung disease, the composition comprising an agent which measures the levels of one or more proteins selected from the group consisting of extracellular vesicle IgG, extracellular vesicle IgG1 and extracellular vesicle IgG4.
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A method for screening a therapeutic agent for a lung disease, the method comprising:
- administering a candidate material for treating a lung disease to a subject, and then measuring protein levels using antibodies against one or more proteins selected from the group consisting of extracellular vesicle IgG, extracellular vesicle IgG1 and extracellular vesicle IgG4 for a sample obtained from the subject.
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Dependencies are inferred from the claim text.