Liver x receptor modulators

A compound or pharmaceutically acceptable salt or prodrug thereof, wherein the compound has a structure corresponding to Formula (I) or Formula (II):

• wherein the A ring is an unsaturated, partially saturated, or saturated carbocyclic or heterocyclic ring containing 5 or 6 ring atoms;
• m is an integer selected from the group consisting of 0, 1, 2, and 3;
• n is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, and 8;
• each RA is independently selected from the group consisting of hydrogen, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, halogen, oxo, —ORAX, SRAY, —S(O)2NRZ1RZ2, —S(O)2RZ1, —S(O)RZ1, —NRZ1RZ2, —N(RZ1)C(O)RZ2, —N(RZ1)S(O)2RZ2, C6-10-aryl, and 5- to 10-membered heteroaryl,
• wherein RAX is hydrogen, C1-6-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, —C(O)—C1-10-alkyl, —C(O)—C6-10-aryl, —C(O)-heteroaryl, —C(O)—O—C1-10-alkyl, —C(O)—O—C6-10-aryl, —C(O)—O-heteroaryl, —C(O)—NRZ1RZ2, —S(O)2NRZ1RZ2, —S(O)2RZ1, C6-10-aryl, or 5- to 10-membered heteroaryl,
• wherein RAY is hydrogen, C1-6-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, —C(O)—C1-10-alkyl, —C(O)—C6-10-aryl, —C(O)-heteroaryl, C6-10-aryl, or 5- to 10-membered heteroaryl,
• wherein each of RZ1 and RZ2 are independently hydrogen, C1-6-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, —(CH2)m—C6-10-aryl, —(CH2)m-5- to 10-membered heteroaryl, hydroxy, or C1-6-alkoxy;
• R3 is oxo or —OR3X, wherein R3X is hydrogen or C1-6-alkyl;
• each of R6A and R6B are independently absent or selected from the group consisting of hydrogen, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, and halogen;
• each of R7A and R7B are independently selected from the group consisting of hydrogen, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, halogen, hydroxy, and oxo;
• R9 and R13 are each independently A-XA—RX,
• wherein A is a C1-C14-alkylene, C1-C14-haloalkylene, C2-C14-alkenylene, C2-C14-haloalkenylene, C2-C14-alkynylene, C2-C14-haloalkynylene, each of which is optionally interrupted by one or more of —O—, —NRZ—, —C(O)—, —C(O)O—, —OC(O)—, —C(O)NRZ—, —NRZC(O)—, —S(O)y—, —S(O)yNRZ—, —NRZS(O)y—, —C(S)NRZ—, —NRZC(S)—, C6-10-aryl, or 5- to 10-membered heteroaryl;
• XA is absent or selected from the group consisting of —O—, —NRZ—, —C(O)—, —C(O)O—, —OC(O)—, —C(O)NRZ—, —NRZC(O)—, —S(O)y—, —S(O)yNRZ—, —NRZS(O)y—, —C(S)NRZ—, —NRZC(S)—, C6-10-aryl, and 5- to 10-membered heteroaryl;
• RX is selected from the group consisting of hydrogen, C1-6-alkyl, C1-6-haloalkyl, C2-6-alkenyl, C2-6-haloalkenyl, C2-6-alkynyl, C2-6-haloalkynyl, C3-7-cycloalkyl, —C(O)—C1-6-alkyl, —C(O)—C6-10-aryl, —C(O)-heteroaryl, —C(O)—NRZ1RZ2, —S(O)2NRZ1RZ2, —NRZ1RZ2, —N(RZ1)C(O)RZ2, —N(RZ1)S(O)2RZ2, C6-10-aryl, and 5- to 10-membered heteroaryl;
• wherein RZ is hydrogen, C1-6-alkyl, C1-6-haloalkyl, C2-6-alkenyl, C2-6-haloalkenyl, C2-6-alkynyl, C2-6-haloalkynyl, C3-7-cycloalkyl, C6-10-aryl, or 5- to 10-membered heteroaryl and y is 0, 1, or 2;
• each of R15A and R15B are independently absent or selected from the group consisting of hydrogen, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, and halogen;
• R16 is X16—RD, wherein X16 is selected from the group consisting of —NRZ—, —NRZS(O)y—, —S(O)yNRZ—, —S(O)y—, —NRZC(O)—, —C(O)NRZ—, —NRZC(S)—, and —C(S)NRZ—;
• and RD is selected from the group consisting of hydrogen, C1-10-alkyl, C1-10-heteroalkyl, C1-10-haloalkyl, C2-10-alkenyl, C2-10-heteroalkenyl, C2-10-haloalkenyl, C2-10-alkynyl, C2-10-heteroalkynyl, C2-10-haloalkynyl, —(CH2)mC6-10-aryl, and —(CH2)m-5- to 10-membered heteroaryl;
• each of R17A and R17B are independently selected from the group consisting of hydrogen, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, halogen, hydroxy, C1-6-alkoxy, C1-10-alkyl-C(O), —C(O)—C1-10-alkyl, —C(O)—C1-10-hydroxyalkyl, —C(O)—C1-10-alkyl-C6-10-aryl, —C(O)—C1-10-alkyl-heteroaryl, —C(O)—C6-10-aryl, —C(O)-heteroaryl, —O—C(O)—C1-6-alkyl, C6-10-aryl, and 5- to 10-membered heteroaryl, or R17A and R17B together form an oxo;
• and
• each independently represents a single bond or a double bond, provided that the bond between carbon C8 and carbon C14 and the bond between carbon C14 and carbon C15 are not both double bonds and provided that if the bond between carbon C5 and carbon C6 is a double bond, then one of R6A or R6B is absent;
• wherein any C6-10-aryl or 5- to 10-membered heteroaryl is optionally substituted with one or more halogen, hydroxy, C1-6-alkyl, C1-6-haloalkyl, or C1-6-alkoxy.