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US 2024/0343680 A1Published application
Process for preparing acyl derivatives
AssigneesCentre National De La Recherche Scientifique, Universite Claude Bernard Lyon 1, Institut National Des Sciences Appliquees De Lyon
InventorsEstelle Metay, Marc Lemaire, Marie-Christine Duclos, Marc Daumas, Olivier Pardigon
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Abstract
The present invention relates to a process for preparing aromatic acyl derivatives of formula (I) using methanesulfonic acid. The invention further relates to methods for preparing biological active ingredients. such as paracetamol.
Claims20
A process for preparing a compound of formula (I):
- in which:
- R1 is a radical selected in the group consisting of:
- a hydroxy group,
- a (C1-C18)alkyl group,
- a (C1-C6)alkoxy group, and
- a halogen group;
- R2 is a radical selected in the group consisting of:
- a (C1-C18)alkyl group,
- a phenyl optionally substituted by at least one hydroxy group, and
- a (C1-C6)alkoxy group;
- comprising the following steps of:
- a) reacting a compound of formula (II):
- R1 being such as above defined,
- with methane sulfonic acid and a compound of formula (III):
- in which:
- R2 is such as above defined, and
- R3 is a radical selected in the group consisting of a hydroxy, a —O—CO—CH3 group, a (C1-C6)alkoxy group, and a chlorine;
- and
- b) recovering said compound of formula (I).
16 more elements
A process for preparing paracetamol comprising the following steps of:
- reacting hydroquinone with ammonium acetate or acetamide and water at a temperature ranging from 240 to 300° C. for a period from 1 min to 12 hours in which 1 to 50 equivalents of ammonium acetate or acetamide relative to hydroquinone are used, wherein the reaction is carried out in the absence of acetic acid;
- and
- recovering paracetamol.
Dependencies are inferred from the claim text.