Potassium channel modulator, composition and application

A compound, wherein the compound has a structure shown in general formula I:

• or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof;
• wherein
• ring A is a benzene ring or a 5- to 8-membered heterocycle containing 1 to 2 heteroatoms selected from N, O, or S;
• R1 is selected from hydrogen, halogen, C1-C8 alkyl, C1-C8 alkoxy, C2-C8 alkenyl, C2-C8 alkenoxy, 3- to 12-membered spiroalkyl, C3-C8 cycloalkyl, C3-C8 cycloalkoxy, C2-C8 heterocycloalkyl, C2-C8 heterocycloalkoxy, C1-C8 alkylthio, C1-C8 alkanoyl, C1-C8 alkylsulfonyl, aminosulfonyl, halo C1-C8 alkyl, halo C1-C8 alkoxy, halo C2-C8 alkenoxy, halo C3-C8 cycloalkyl, halo C3-C8 cycloalkoxy, halo C2-C8 heterocycloalkyl, halo C2-C8 heterocycloalkoxy, and the alkyl, alkoxy, alkenyl, alkenoxy, cycloalkyl, cycloalkoxy, heterocycloalkyl, heterocycloalkoxy, alkylthio, alkanoyl, alkylsulfonyl, aminosulfonyl are unsubstituted or substituted by R8;
• each R2 is independently selected from hydrogen, halogen, C1-C8 alkyl, C1-C8 alkoxy, C3-C8 cycloalkyl, C3-C8 cycloalkoxy, C2-C8 heterocycloalkyl, C2-C8 heterocycloalkoxy, halo C1-C8 alkyl, halo C1-C8 alkoxy, halo C3-C8 cycloalkyl, halo C3-C8 cycloalkoxy, halo C2-C8 heterocycloalkyl, halo C2-C8 heterocycloalkoxy;
• or two R2 groups are attached to the same atom, and the two R2 groups are different or the same, and the two R2 groups, together with the atom to which they are attached, form a 3- to 6-membered cycloalkyl ring or a 3- to 6-membered heterocycle;
• R4, R5, R6, R7, R8 are each independently selected from hydrogen, halogen, C1-C8 alkyl, C1-C8 alkoxy, C3-C8 cycloalkyl, C3-C8 cycloalkoxy, C2-C8 heterocycloalkyl, C2-C8 heterocycloalkoxy, halo C1-C8 alkyl, halo C1-C8 alkoxy, halo C3-C8 cycloalkyl, halo C3-C8 cycloalkoxy, halo C2-C8 heterocycloalkyl, halo C2-C8 heterocycloalkoxy, 3- to 12-membered spiroalkyl;
• n is selected from 0, 1, 2;
• m is selected from 0, 1, 2, 3, 4, 5;
• X1 and X2 are each independently selected from —CRaRb, —NRa, —O—, —C(O)—, —S—, —S(O)—, —S(O)2—;
• Ra and Rb are each independently selected from hydrogen, halogen, hydroxyl, amino, C1-C8 alkyl, C1-C8 alkoxy, C1-C8 alkylamino, C3-C8 cycloalkyl, halo C1-C8 alkyl, halo C1-C8 alkoxy, halo C3-C8 cycloalkyl;
• indicates the presence or absence of a chemical bond;
• Z is selected from O or (CH2)p, and p is an integer of 1 to 6;
• R3 is C1-C8 alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkenyl, C2-C8 alkenyl, or C2-C8 alkynyl, wherein the C1-C8 alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkenyl, C2-C8 alkenyl, or C2-C8 alkynyl is unsubstituted or substituted by one or more than one substituent selected from halogen, nitro, cyano, amino, or hydroxyl.