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AssigneeAdel Inc.
InventorJi Seon PARK
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The present invention relates to an animal model in which social dominance is absent, and a pharmaceutical composition for preventing or treating diseases associated with the absence or reduction of social dominance. In an animal model, according to the present invention, social dominance is absent through inhibiting of the expression or activity of a CREB-regulated transcription coactivator 3 (CRTC3) gene or protein, and the animal model can be used as a model for diseases associated with the absence or reduction of social dominance. In addition, the present invention enables the prevention, alleviation or treatment of diseases associated with the absence or reduction of social dominance by using a composition containing agonists for brain epidermal growth factor (EGF) receptors.
An animal model lacking social dominance, in which expression or activity of CREB-regulated transcription coactivator 3 (CRTC3) gene or protein is suppressed.
A method of producing an animal model lacking social dominance, comprising suppressing expression or activity of CREB-regulated transcription coactivator 3 (CRTC3) gene or protein.
A pharmaceutical composition for preventing or treating a disease related to lack or reduction of social dominance, comprising as an active ingredient an agonist for epidermal growth factor (EGF) receptor in the brain.
Dependencies are inferred from the claim text.