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US 2024/0299625 A1Published application
Methods and compositions for treating retinal diseases and conditions
AssigneeLineage Cell Therapeutics, Inc.
InventorsRami Skaliter, Gary Hogge, Jordi Mones, Avi Ben Shabat, Lilach Alon, Ravid Tikotzki, Dana Hayoun Neeman, Ofer Wiser
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Abstract
Provided herein are methods, compositions of matter, and devices for treating diseases and illnesses of the eye, including retinal conditions such as macular degeneration.
Claims23
A method for assessing the progression of an area of retinal atrophy in a retina of a subject, comprising
- a) defining an area of geographic atrophy or complete RPE and outer retinal atrophy (cRORA) within an external limiting membrane (ELM) border of the retina at a first time point;
- b) marking and measuring an ELM border or ELM border descend using optical coherence tomography (OCT), wherein the ELM border is the boundary of the atrophy and the ELM border descend is the delimitation of the area with near-total photoreceptor depletion by histology;
- c) calculating an area included inside the ELM border to define a first calculated area, and determining a square root transformation (SQRT) of the first calculated area;
- and
- d) defining the rate of progression of the atrophy by comparing the SQRT of the first calculated area with a control;
- wherein if the rate of progression of the atrophy in the subject is greater than the control, the subject is administered a transplantation of retinal pigment epithelium (RPE) cells.
3 more elements
(canceled)
A method for assessing restoration or regeneration of a retina of a subject in areas within an atrophy area comprising:
- a) defining and using OCT biomarkers as the boundary of any retinal layer;
- b) marking and measuring boundaries of any retinal layer using the OCT;
- c) calculating the length/width and volume of a specific retinal layer;
- d) defining the level of restoration or regeneration by comparing the calculated ELM areas from steps (a)-(c);
- and
- e) detecting newly present areas of ELM;
- wherein if newly present areas of ELM are detected, then the subject is administered a transplantation of retinal pigment epithelium (RPE) cells.
4 more elements
22-35. (canceled)
Dependencies are inferred from the claim text.