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US 2024/0294959 A1Published application
Cellular production of bioproducts
AssigneeInbiose N.V.
InventorsJoeri Beauprez, Pieter Coussement, Thomas Decoene, Annelies Vercauteren
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AssigneeInbiose N.V.
InventorsJoeri Beauprez, Pieter Coussement, Thomas Decoene, Annelies Vercauteren
Estimating the term…
The present invention is in the technical field of synthetic biology and metabolic engineering. More particularly, the present invention is in the technical field of metabolically engineered cells and use of said cells in a cultivation, preferably fermentation. The present invention describes a metabolically engineered cell and a method by cultivation, preferably fermentation, with said cell for production of a bioproduct. More specifically, the present invention describes a metabolically engineered cell and a method by cultivation, preferably fermentation, with said cell for production of an N-acetylneuraminic acid (Neu(n)Ac)-containing compound, wherein (n) is 4, 5, 7, 8 or 9 or a combination thereof. The metabolically engineered cell comprises a pathway for production of said Neu(n)Ac-containing compound and is modified in the expression or activity of at least one NeuNAc synthase according to the present invention. Furthermore, the present invention provides for purification of said Neu(n)Ac-containing compound from the cultivation.
1-56. (canceled)
A metabolically engineered cell for producing a bioproduct selected from monosaccharide, activated monosaccharide, phosphorylated monosaccharide, disaccharide, oligosaccharide, aglycon, glycolipid and glycoprotein, the cell comprising:
Dependencies are inferred from the claim text.