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US 2024/0294916 A1Published application
Small interfering rna targeting cfb and uses thereof
OwnerChunyang ZHANG, Xin GENG +2inventors
InventorsChunyang ZHANG, Xin GENG, Shiyu WANG, Weimin WANG
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Abstract
This disclosure relates to isolated oligonucleotides comprising duplex regions targeting human CFB mRNA, and delivery systems, kits and compositions comprising the same, and methods of using the same for inhibiting or downregulating CFB gene expression.
Claims26
An isolated oligonucleotide comprising an antisense strand and a sense strand, selected from:
- i) an isolated oligonucleotide comprising:
- an antisense strand of nucleic acid sequence according to SEQ ID NO:
- 24 (5′ UGUCAUAAAAUUCAGGAAUUCC 3′), and
- a sense strand of nucleic acid sequence according to SEQ ID NO:
- 58 (5′ AAUUCCUGAAUUUUAUGACA 3′);
- ii) an isolated oligonucleotide comprising:
- an antisense strand of nucleic acid sequence according to SEQ ID NO:
- 22 (5′ UUAAAAUUCAGGAAUUCCUGCU 3′), and
- a sense strand of nucleic acid sequence according to SEQ ID NO:
- 56 (5′ CAGGAAUUCCUGAAUUUUAA 3′);
- and
- iii) an isolated oligonucleotide comprising:
- an antisense strand of nucleic acid sequence according to SEQ ID NO:
- 15 (5′ UAACACAUGUUGCUCAUUGUCU 3′), and
- a sense strand of nucleic acid sequence according to SEQ ID NO:
- 49 (5′ ACAAUGAGCAACAUGUGUUA 3′).
13 more elements
Dependencies are inferred from the claim text.